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Coenzyme Q10 improves blood pressure and glycemic control: a controlled trial in subjects with type 2 diabetes
Objective: Our objective was to assess effects of dietary supplementation with coenzyme Q10 (CoQ) on blood pressure and glycaemic control in subjects with type 2 diabetes, and to consider oxidative stress as a potential mechanism for any effects. Subjects and design: Seventy-four subjects with uncomplicated type 2 diabetes and dyslipidaemia were involved in a randomised double blind placebo-controlled 2x2 factorial intervention.
Setting: The study was performed at the University of Western Australia, Department of Medicine at Royal Perth Hospital, Australia.
Interventions: Subjects were randomly assigned to receive an oral dose of 100 mg CoQ twice daily (200mg/day), 200 mg fenofibrate each morning, both or neither for 12 weeks.
Main outcome measures: We report an analysis and discussion of the effects of CoQ on blood pressure, on long-term glycaemic control measured by glycated haemoglobin (HbA1c), and on oxidative stress assessed by measurement of plasma F2- isoprostanes.
Results: Fenofibrate did not alter blood pressure, HbA1c, or plasma F2-isoprostanes. There was a 3-fold increase in plasma CoQ concentration (3.4 ± 0.3 mmol/l, P < 0.001) as a result of CoQ supplementation. The main effect of CoQ was to significantly decrease systolic (— 6.1 ±2.6mmHg, P = 0.021) and diastolic (— 2.9± 1.4mmHg, P = 0.048) blood pressure and HbA1c(— 0.37± 0.17%, P = 0.032). Plasma F2-isoprostane concentrations were not altered by CoQ (0.14 ± 0.15 mmol/l, P = 0.345). Conclusions: These results show that CoQ supplementation may improve blood pressure and long-term glycemic control in subjects with type 2 diabetes, but these improvements were not associated with reduced oxidative stress, as assessed by F2- isoprostanes.
University of Western Australia Department of Medicine and HeartSearch, Royal Perth Hospital, Perth, Western Australia, Australia; and Department of Cardiology, Royal Perth Hospital, Perth, Western Australia, Australia
Sponsorship: This study was supported by a grant from the NH&MRC, Australia.
European Journal of Clinical Nutrition (2002) 56, 1137-1142. doi:10.1038/sj.ejcn.1601464
JM Hodgson, GF Watts, DA Playford, V Burke and KD Croft