با توجه به حجم انبوه اطلاعات موجود در فضای مجازی ٬ شرکت پرارین پارس سعی نموده تا مقالات مرتبط و قابل استناد در ارتباط با محصولات مختلف را برای استفاده مراجعه کنندکان در یک مکان تجمیع نماید.
Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging
Female reproductive capacity declines dramatically in the fourth decade of life as a result of an age-related decrease in oocyte quality and quantity. The primary causes of reproductive aging and the molecular factors responsible for decreased oocyte quality remain elusive. Here, we show that aging of the female germ line is accompanied by mitochondrial dysfunction associated with decreased oxidative phosphorylation and reduced Adenosine tri-phosphate (ATP) level. Diminished expression of the enzymes responsible for CoQ production, Pdss2 and Coq6, was observed in oocytes of older females in both mouse and human. The age-related decline in oocyte quality and quantity could be reversed by the administration of CoQ10. Oocyte- specific disruption of Pdss2 recapitulated many of the mitochondrial and reproductive phenotypes observed in the old females including reduced ATP production and increased meiotic spindle abnormalities, resulting in infertility. Ovarian reserve in the oocyte-specific Pdss2-deficient animals was diminished, leading to premature ovarian failure which could be prevented by maternal dietary administration of CoQ10. We conclude that impaired mitochondrial performance created by suboptimal CoQ10 availability can drive age-associated oocyte deficits causing infertility.
Assaf Ben-Meir, Eliezer Burstein, Aluet Borrego- Alvarez, Jasmine Chong, Ellen Wong, Tetyana Yavorska, Taline Naranian, Maggie Chi, Ying Wang, Yaakov Bentov, Jennifer Alexis, James Meriano, Hoon-Ki Sung, David L. Gasser, Kelle H. Moley, Siegfried Hekimi, Robert F. Casper and Andrea Jurisicova
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 25 Orde Street, Toronto, ON M5T 3H7, Canada
TCART Fertility Partners, 150 Bloor W, Toronto, ON M5S 2X9, Canada Department of Physiology, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada
Department of Obstetrics and Gynecology, Washington University in St. Louis, 660 S. Euclid Avenue, St. Louis, MO 63110, USA Department of Biology, McGill University, 3649 Promenade Sir William Osler, Montreal, QC H3G 0B1, Canada
Department of Obstetrics and Gynecology, University of Toronto, 92 College Street, Toronto ON, M5G 1L4, Canada
LifeQuest Centre for Reproductive Medicine, 655 Bay St, Toronto, ON M5G 2K4, Canada
Department of Genetics, University of Pennsylvania, 575 Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA, 19104-6145, USA